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FLASH GENE

Symbol

DNA2

contributors: mct/pgu - updated : 17-11-2016

HGNC name	DNA replication helicase 2 homolog (yeast)
HGNC id	2939

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

PEOA6 , SCKL8

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       in adult-onset disorders of mtDNA maintenance tumoral somatic mutation       mutations in DNA2, found in estrogen-dependent cancers, are clustered in the helicase and nuclease domains, suggesting activity impairment

Susceptibility

Variant & Polymorphism

Candidate gene	appropriate candidate for molecular screening in subjects with sporadic or familial PEO with ascertained instability of muscle mtDNA
Marker
Therapy target

ANIMAL & CELL MODELS