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FLASH GENE
Symbol HOOK2 contributors: mct - updated : 22-12-2011
HGNC name hook homolog 2 (Drosophila)
HGNC id 19885
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal domain directly binds to centriolin/CEP110
    • HOMOLOGY
    intraspecies homolog to HOOK1 and HOOK3
    Homologene
    FAMILY hook family
    CATEGORY motor/contractile , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • localizes to the centrosome through all phases of the cell cycle
  • in retinal epithelial cells, localizes at the Golgi apparatus and centrosome/basal body, a strategic partitioning for ciliogenesis
    • basic FUNCTION
  • required for endocytic trafficking
  • required for protein transport from the ER to the golgi complex
  • potentially contributes to the establishment and maintenance of centrosomal structure and function
  • contributes to the establishment and maintenance of the pericentrosomal localization of aggresomes by promoting the microtubule-based delivery of protein aggregates to pericentriolar aggresomes
  • linker protein that is essential for regulation of the micotubules network at the centrosome, as a binding partner of CENPF
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ZC3H14 binds to HOOK2, a protein previously implicated in aggresome formation
  • binding partner of CENPF
  • interacts with PCM1 in a complex that also contains RAB8A and regulates a limiting step required for further initiation of ciliogenesis after centriole maturation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS