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FLASH GENE
Symbol HOOK2 contributors: mct - updated : 22-12-2011
HGNC name hook homolog 2 (Drosophila)
HGNC id 19885
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
Nervousbrainhindbrainmedulla oblongata  
 braindiencephalonamygdala  
Respiratorylung    
 respiratory tractlarynx   
Visualeyeretina    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Visualepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal domain directly binds to centriolin/CEP110
    • HOMOLOGY
    intraspecies homolog to HOOK1 and HOOK3
    Homologene
    FAMILY hook family
    CATEGORY motor/contractile , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • localizes to the centrosome through all phases of the cell cycle
  • in retinal epithelial cells, localizes at the Golgi apparatus and centrosome/basal body, a strategic partitioning for ciliogenesis
    • basic FUNCTION
  • required for endocytic trafficking
  • required for protein transport from the ER to the golgi complex
  • potentially contributes to the establishment and maintenance of centrosomal structure and function
  • contributes to the establishment and maintenance of the pericentrosomal localization of aggresomes by promoting the microtubule-based delivery of protein aggregates to pericentriolar aggresomes
  • linker protein that is essential for regulation of the micotubules network at the centrosome, as a binding partner of CENPF
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ZC3H14 binds to HOOK2, a protein previously implicated in aggresome formation
  • binding partner of CENPF
  • interacts with PCM1 in a complex that also contains RAB8A and regulates a limiting step required for further initiation of ciliogenesis after centriole maturation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS