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FLASH GENE

Symbol

HOOK2

contributors: mct - updated : 22-12-2011

HGNC name	hook homolog 2 (Drosophila)
HGNC id	19885

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.2      Physical location : 12.873.816 - 12.886.434
Synonym name	hook2 protein
Synonym symbol(s)	HK2, hHK2

DNA

TYPE	functioning gene
STRUCTURE	12.62 kb     22 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001100176 22 - 2622 - 717 - 2007 17140400 NM_013312 23 - 2628 - 719 - 2007 17140400

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Nervous brain hindbrain medulla oblongata       brain diencephalon amygdala     Respiratory lung           respiratory tract larynx       Visual eye retina       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Visual epithelial cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	C-terminal domain directly binds to centriolin/CEP110

HOMOLOGY

intraspecies

homolog to HOOK1 and HOOK3

Homologene

FAMILY

hook family

CATEGORY

motor/contractile , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
text	localizes to the centrosome through all phases of the cell cycle
	in retinal epithelial cells, localizes at the Golgi apparatus and centrosome/basal body, a strategic partitioning for ciliogenesis

basic FUNCTION	required for endocytic trafficking
	required for protein transport from the ER to the golgi complex
	potentially contributes to the establishment and maintenance of centrosomal structure and function
	contributes to the establishment and maintenance of the pericentrosomal localization of aggresomes by promoting the microtubule-based delivery of protein aggregates to pericentriolar aggresomes
	linker protein that is essential for regulation of the micotubules network at the centrosome, as a binding partner of CENPF

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	ZC3H14 binds to HOOK2, a protein previously implicated in aggresome formation
	binding partner of CENPF
	interacts with PCM1 in a complex that also contains RAB8A and regulates a limiting step required for further initiation of ciliogenesis after centriole maturation

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS