basic FUNCTION
| involved in planar cell polarity |
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required for normal localization of specific intraflagellar transport |
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required for the localization of G protein-coupled receptors to primary cilia on central neurons |
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mediate LEPR trafficking and impaired LEPR signaling underlies energy imbalance in the disease |
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probably has a nuclear role by virtue of the presence of a biologically confirmed nuclear export signal |
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is required for BBSome formation, and BBS7 and BBS2 depend on each other for protein stability |
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is involved in specific membrane protein localization to cilia |
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play a central role in the regulation of the actin cytoskeleton and control the cilia length through alteration of RHOA levels |