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FLASH GENE
Symbol A1CF contributors: mlc - updated : 10-01-2011
HGNC name APOBEC1 complementation factor
HGNC id 24086
Location 10q11.23      Physical location : 52.566.326 - 52.645.435
Synonym name
  • APOBEC-1 stimulating protein
  • apo-B RNA editing protein
  • apobec-1 complementation factor (ACF) (ASP)
  • Synonym symbol(s) ASP, ACF64, ACF65, ACF, APOBEC1CF, RP11-564C4.2
    DNA
    TYPE functioning gene
    STRUCTURE 79.11 kb     13 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 splicing 9269 64.1 586 - 2002 11815617
  • 13 exons
  • also referred to as the wild type
  • 13 splicing 9293 65.1 594 - 2002 11815617
  • 13 exons
  • using an alternate splice acceptor site on exon 12 compared to variant 1
  • containing a unique 8 aa internal region compared to isoform 1
  • 13 splicing 9364 64.9 594 - 2002 11815617
  • 13 exons
  • missing exon 2 but including exon 5 compared to variant 1
  • using a downstream translation initiation site and having a unique N-terminus compared to isoform 1
  • - - 9362 - 586 - -
    - - 9529 - 602 - -
    - - 9412 - 594 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  moderately
     liver   highly
     stomach   highly
    Reproductivemale systemprostate   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal 320 AAs retained RNA-binding selectivity and supported complementation of editing activity and in addition demonstrate a novel RNA-bridged multimerization of A1CF
  • three non-identical RNA recognition motifs (RRM) domains
  • a 41-residue motif (ANS) in the auxiliary domain functioning as an authentic nuclear localization signal
  • secondary structure RRMs are a well-described structural fold consisting of 4 antiparallel beta-strands packed by two alpha helices
    HOMOLOGY
    interspecies homolog to rattus Acf (94.2 pc)
    Homologene
    FAMILY
  • hnRNP R family of RNA-binding proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    text
  • predominantly localized to heterochromatin
  • found at the outer surface of the endoplasmic reticulum
  • basic FUNCTION
  • may be involved in RNA editing or RNA processing events
  • regulating nucleocytoplasmic import and shuttling
  • being responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA
  • being probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine
  • protecting the edited APOB mRNA from nonsense-mediated decay
  • RNA-binding protein that facilitated site-specific targeting of apoB mRNA for C to U editing
  • CELLULAR PROCESS nucleotide
    PHYSIOLOGICAL PROCESS
    text
  • mRNA processing and editing
  • PATHWAY
    metabolism
    signaling
    a component
  • essential component of the apolipoprotein B mRNA editing enzyme complex
  • interacting with KHSRP/KRSP which may confer stability on the editing complex
  • INTERACTION
    DNA
    RNA
  • binding to APOB mRNA
  • binding to single-stranded RNA
  • small molecule
    protein
  • binding to the protein carrier, transportin 2
  • interacting with the nuclear import protein TNPO2/TRN2 which may be responsible for its transport into the nucleus
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS