basic FUNCTION
| acting sequentially with EHD1 in the transport of proteins from early endosomes to the endosomal recycling compartement and back to the plasma membrane |
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serving as a molecular link between VPS45 and the Rab5 GTPase |
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ZFYVE20 and EHD1 may act sequentially in the transport of proteins from early endosomes to the endosomal recycling compartment and back to the plasma membrane |
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RBSN is a RAB5 effector that bridges an interaction between Rab5 and the Sec1/Munc18-family protein VPS45 |
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VPS45 interacts with ZFYVE20 and carries out multiple functions in the endocytic/secretory pathways |
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VPS45 and ZFYVE20 are implicated in post early endosome transport, and their interaction potentially serves as a nexus to promote bidirectional transport along the endosome-to-recycling compartment and endosome-to-Golgi axes |
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EEA1 and ZFYVE20 facilitate endosome tethering, sorting, and fusion |
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regulates endocytosis at the apical side of the wing epithelium and, surprisingly, further uncovered a novel function of this protein in planar cell polarity (PCP) |