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FLASH GENE
Symbol PRAF2 contributors: mct - updated : 01-12-2010
HGNC name PRA1 domain family, member 2
HGNC id 28911
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Rab-acceptor motif, indicating a function in vesicle formation at the Golgi complex
  • four-transmembrane domains
    • HOMOLOGY
    interspecies ortholog to murine DXImx39e
    intraspecies homolog to JWA and glutamate transporter-associated protein 3-18 (GTRAP3-18)
    homolog to PRAF1, PRAF3
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    text co-localises with calnexin in the endoplasmic reticulum and with the mannose 6-phosphate receptor in the Golgi
    basic FUNCTION
  • may function in trafficking and membrane localisation of the receptor, possibly also other receptors or amino acid transporters
  • plays a role in the regulation of intracellular protein transport
  • potential important physiological function by participating in multiple aspects of synaptic vesicles maturation, transport, and signal transmission
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • co-localise and heterodimerise with JWA, and GTRAP3-18
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CCR5
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer tissues of the breast, colon, lung, and ovary
    tumoral     --over  
    in malignant glioma
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate prognostic marker of neuroblastoma
    Marker
    Therapy target
  • candidate molecular target for therapeutic intervention in gliomas
    • ANIMAL & CELL MODELS