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FLASH GENE

Symbol

PRAF2

contributors: mct - updated : 01-12-2010

HGNC name	PRA1 domain family, member 2
HGNC id	28911

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007213 3 - 1263 NP_009144 19.3 178 - 2006 16481131

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly Homo sapiens Endocrine pancreas       highly Homo sapiens Lymphoid/Immune spleen       highly Homo sapiens Nervous brain limbic system hippocampus   highly Homo sapiens   brain hindbrain cerebellum   highly Homo sapiens Reproductive male system prostate     moderately Respiratory lung       highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens Nervous Purkinje cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a Rab-acceptor motif, indicating a function in vesicle formation at the Golgi complex
	four-transmembrane domains

HOMOLOGY

interspecies

ortholog to murine DXImx39e

intraspecies	homolog to JWA and glutamate transporter-associated protein 3-18 (GTRAP3-18)
	homolog to PRAF1, PRAF3

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,endosome
text	co-localises with calnexin in the endoplasmic reticulum and with the mannose 6-phosphate receptor in the Golgi

basic FUNCTION	may function in trafficking and membrane localisation of the receptor, possibly also other receptors or amino acid transporters
	plays a role in the regulation of intracellular protein transport
	potential important physiological function by participating in multiple aspects of synaptic vesicles maturation, transport, and signal transmission

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

co-localise and heterodimerise with JWA, and GTRAP3-18

INTERACTION

DNA

RNA

small molecule

protein

interacting with CCR5

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in cancer tissues of the breast, colon, lung, and ovary tumoral     --over   in malignant glioma

Susceptibility

Variant & Polymorphism

Candidate gene	candidate prognostic marker of neuroblastoma
Marker
Therapy target	candidate molecular target for therapeutic intervention in gliomas

ANIMAL & CELL MODELS