basic FUNCTION
| involved in protein transport, membrane trafficking or cell signaling during hematopoietic maturation |
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required for the localization of G protein-coupled receptors to primary cilia on central neurons |
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having a small monomeric GTPase activity |
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is essential for flagellum biogenesis |
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involved in planar cell polarity |
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mediate LEPR trafficking and impaired LEPR signaling underlies energy imbalance in the disease |
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role in mammalian ciliary (dis)assembly and Wnt signaling |
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modulating membrane trafficking at the base of the ciliary organelle |
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targets the BBSome to cilia when GTP bound and recruits the BBSome to membranes to assemble a polymerized coat |
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play a central role in the regulation of the actin cytoskeleton and control the cilia length through alteration of RHOA levels |
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IFT27 separates from IFT-B inside cilia to promote ARL6 activation, BBSome coat assembly, and subsequent ciliary exit |
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localizes at the base of primary cilium, controls ciliogenesis and HH signaling |