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FLASH GENE
Symbol CD99L2 contributors: mct - updated : 18-02-2016
HGNC name CD99 antigen-like 2
HGNC id 18237
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies ortholog to murine Mic2l1
ortholog to murine CD99
intraspecies paralog to CD99
Homologene
FAMILY
CATEGORY antigen
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
    intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,organelle,membrane
basic FUNCTION
  • CD99 and CD99L2 act independently of PECAM1 in leukocyte extravasation and cooperate in an independent way to help neutrophils overcome the endothelial basement membrane
  • is an essential endothelial Ag for leukocyte extravasation, which does not require homophilic interactions with CD99L2 on leukocytes
  • play likely a role in leukocyte extravasation under various inflammatory conditions
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking CD99L2 had a defective inflammatory response in the thioglycollate peritonitis model with a greater than 80p100 block in neutrophil infiltration and a nearly complete block in monocyte emigration into the peritoneal cavity