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FLASH GENE

Symbol

CD99L2

contributors: mct - updated : 18-02-2016

HGNC name	CD99 antigen-like 2
HGNC id	18237

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	132.48 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_031462 11 - 3736 NP_113650 - 262 - 2003 12706889 NM_134446 9 - 3589 NP_604395 - 213 - 2003 12706889 NM_134445 8 - 3520 NP_604394 - 190 - 2003 12706889 NM_001184808 9 - 3517 NP_001171737 - 189 - 2003 12706889 NM_001242614 12 - 3754 NP_001229543 - 272 - 2003 12706889

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Cardiovascular heart       moderately Digestive liver       moderately Endocrine pancreas       highly Nervous brain       highly Reproductive male system prostate     moderately Respiratory lung       moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial secretory glandular endocrine

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Homo sapiens Cardiovascular endothelial cell Homo sapiens Lymphoid/Immune lymphocyte Homo sapiens Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to murine Mic2l1
	ortholog to murine CD99

intraspecies

paralog to CD99

Homologene

FAMILY

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane

basic FUNCTION	CD99 and CD99L2 act independently of PECAM1 in leukocyte extravasation and cooperate in an independent way to help neutrophils overcome the endothelial basement membrane
	is an essential endothelial Ag for leukocyte extravasation, which does not require homophilic interactions with CD99L2 on leukocytes
	play likely a role in leukocyte extravasation under various inflammatory conditions

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mice lacking CD99L2 had a defective inflammatory response in the thioglycollate peritonitis model with a greater than 80p100 block in neutrophil infiltration and a nearly complete block in monocyte emigration into the peritoneal cavity