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FLASH GENE
Symbol TBKBP1 contributors: mct/npt - updated : 10-10-2009
HGNC name TBK1 binding protein 1
HGNC id 30140
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • potassium channel HCN family
    • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text located in dendrites and spines (Liebau 2009)
    basic FUNCTION
  • part of the interaction network in the TNF/NFKB pathway
  • DNA-dependent RNA polymerase catalyzing
  • the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
  • upon infection with Sendai virus, is essential for the efficient induction of IRF-dependent transcriptionb (Ryzhakov 2007)
  • essential for the efficient induction of IRF-dependent transcription, as are two further TBK1 adaptors, TANK and AZI2 (Ryzhakov 2007)
  • TANK with AZI2 or TBKBP1 assemble TBK1 and IKKE complexes (Chau 2008)
  • could be involved in the linkage between molecules of the postsynaptic density and the cytoskeleton (Liebau 2009)
  • may play a role as a linker molecule (interaction partner of TBK1 in the signaling pathway of NFKB and a signaling cascade that is known to be important for neuronal differentiation and synaptic plasticity (Liebau 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds TBK1 and IKBKE but not related kinases (Rhyzhakov 2007)
  • binds to the PDZ domain of ProSAP2/SHANK3 (Liebau 2009)
  • interacts with the actin cytoskeleton and could be a modulator of postsynaptic morphology in response to different signaling cascades including the NFKB pathway (Liebau 2009)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS