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FLASH GENE
Symbol TBKBP1 contributors: mct/npt - updated : 10-10-2009
HGNC name TBK1 binding protein 1
HGNC id 30140
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 4150 - 615 - Ryzhakov (2007)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly
Nervousbrain   predominantly
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal moderately
cell lineage
cell lines
  • three pooled meningiomas
  • duodenal adenocarcinoma
    • fluid/secretion cord blood
    at STAGE
    physiological period embryo, pregnancy
    Text cord blood
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • potassium channel HCN family
    • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text located in dendrites and spines (Liebau 2009)
    basic FUNCTION
  • part of the interaction network in the TNF/NFKB pathway
  • DNA-dependent RNA polymerase catalyzing
  • the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
  • upon infection with Sendai virus, is essential for the efficient induction of IRF-dependent transcriptionb (Ryzhakov 2007)
  • essential for the efficient induction of IRF-dependent transcription, as are two further TBK1 adaptors, TANK and AZI2 (Ryzhakov 2007)
  • TANK with AZI2 or TBKBP1 assemble TBK1 and IKKE complexes (Chau 2008)
  • could be involved in the linkage between molecules of the postsynaptic density and the cytoskeleton (Liebau 2009)
  • may play a role as a linker molecule (interaction partner of TBK1 in the signaling pathway of NFKB and a signaling cascade that is known to be important for neuronal differentiation and synaptic plasticity (Liebau 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds TBK1 and IKBKE but not related kinases (Rhyzhakov 2007)
  • binds to the PDZ domain of ProSAP2/SHANK3 (Liebau 2009)
  • interacts with the actin cytoskeleton and could be a modulator of postsynaptic morphology in response to different signaling cascades including the NFKB pathway (Liebau 2009)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS