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FLASH GENE

Symbol

GRAMD4

contributors: mct/npt - updated : 18-10-2023

HGNC name	GRAM domain containing 4
HGNC id	29113

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION

TP53-independent pro-apoptotic target of E2F1, which localizes to mitochondria

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with TP73 (TP73 is able to trigger apoptosis via the mitochondrial pathway by a new mechanism using pro-apoptotic GRAMD4 as mediator, and strongly support its TP53-like function)
	critical role of RTN4 and GRAMD4 in trafficking of TLR9
	GRAMD4 interacted with MAP3K7 to promote its protein degradation, thus, resulting in the inactivation of MAPK (Mitogen-activated protein kinase) and NFKB1 pathways
	GRAMD4 inhibits the migration and metastasis of hepatocellular carcinoma, mainly by recruiting ITCH to promote the degradation of MAP3K7, which leads to the inactivation of MAPK and NFKB1 signalling pathways

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS