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FLASH GENE
Symbol GRAMD4 contributors: mct/npt - updated : 18-10-2023
HGNC name GRAM domain containing 4
HGNC id 29113
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 4500 66.4 578 - 2005 15565177
18 - 2161 - 561 - 2005 15565177
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • TP53-independent pro-apoptotic target of E2F1, which localizes to mitochondria
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TP73 (TP73 is able to trigger apoptosis via the mitochondrial pathway by a new mechanism using pro-apoptotic GRAMD4 as mediator, and strongly support its TP53-like function)
  • critical role of RTN4 and GRAMD4 in trafficking of TLR9
  • GRAMD4 interacted with MAP3K7 to promote its protein degradation, thus, resulting in the inactivation of MAPK (Mitogen-activated protein kinase) and NFKB1 pathways
  • GRAMD4 inhibits the migration and metastasis of hepatocellular carcinoma, mainly by recruiting ITCH to promote the degradation of MAP3K7, which leads to the inactivation of MAPK and NFKB1 signalling pathways
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS