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FLASH GENE
Symbol GRAMD4 contributors: mct/npt - updated : 18-10-2023
HGNC name GRAM domain containing 4
HGNC id 29113
Location 22q13.31      Physical location : 47.022.657 - 47.075.687
Synonym name
  • KIAA0767 protein
  • death-inducing-protein
  • DIP protein
    • Synonym symbol(s) KIAA0767, MGC90497, MGC149847, dA59H18.1, dJ439F8.1, DIP
    DNA
    TYPE functioning gene
    STRUCTURE 53.04 kb     18 Exon(s)
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 4500 66.4 578 - 2005 15565177
    18 - 2161 - 561 - 2005 15565177
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • TP53-independent pro-apoptotic target of E2F1, which localizes to mitochondria
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TP73 (TP73 is able to trigger apoptosis via the mitochondrial pathway by a new mechanism using pro-apoptotic GRAMD4 as mediator, and strongly support its TP53-like function)
  • critical role of RTN4 and GRAMD4 in trafficking of TLR9
  • GRAMD4 interacted with MAP3K7 to promote its protein degradation, thus, resulting in the inactivation of MAPK (Mitogen-activated protein kinase) and NFKB1 pathways
  • GRAMD4 inhibits the migration and metastasis of hepatocellular carcinoma, mainly by recruiting ITCH to promote the degradation of MAP3K7, which leads to the inactivation of MAPK and NFKB1 signalling pathways
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS