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FLASH GENE
Symbol AMN contributors: mct - updated : 12-12-2018
HGNC name amnionless homolog (mouse)
HGNC id 14604
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one VWFC domain
conjugated GlycoP
isoforms Precursor
HOMOLOGY
interspecies ortholog to murine Amn
homolog to rattus Amn
Homologene
FAMILY
CATEGORY receptor membrane
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • modulating bone morphogenetic protein (BMP) receptor function, serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding
  • necessary for efficient absorption of vitamin B12
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • functioning in the same pathway as cubilin (CUBN) and forms a complex designated cubam, which is essential for endocytosis/trancytosis of several ligands
  • CUBN functions as a multi-ligand receptor by binding to the transmembrane protein, AMN, and AMN -mediated glycosylation is crucial for cell surface targeting of CUBN in renal and intestinal cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MGA1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS