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FLASH GENE
Symbol ADSS1 contributors: mct - updated : 07-04-2021
HGNC name adenylosuccinate synthase 1
HGNC id 20093
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
mono polymer homomer , dimer
HOMOLOGY
interspecies ortholog to murine AdSS1, muscular
Homologene
FAMILY adenylosuccinate synthetase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • playing an important role in the de novo pathway of purine nucleotide biosynthesis
  • adenylosuccinate synthase and ligase activity
  • playing a potential role in muscle metabolism
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    pathway of purine nucleotide biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • magnesium ion binding
  • GTP ion binding
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MPD5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    is a novel somatic alteration in lung carcinogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS