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FLASH GENE
Symbol ADSS1 contributors: mct - updated : 07-04-2021
HGNC name adenylosuccinate synthase 1
HGNC id 20093
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   predominantly
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Muscularstriatumskeletal predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
mono polymer homomer , dimer
HOMOLOGY
interspecies ortholog to murine AdSS1, muscular
Homologene
FAMILY adenylosuccinate synthetase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • playing an important role in the de novo pathway of purine nucleotide biosynthesis
  • adenylosuccinate synthase and ligase activity
  • playing a potential role in muscle metabolism
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    pathway of purine nucleotide biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • magnesium ion binding
  • GTP ion binding
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MPD5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    is a novel somatic alteration in lung carcinogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS