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FLASH GENE
Symbol ADSSL1 contributors: - updated : 15-11-2006
HGNC name adenylosuccinate synthase like 1
HGNC id 20093
Location 14q32.33      Physical location : 105.190.533 - 105.213.645
Synonym symbol(s) FLJ38602
DNA
TYPE functioning gene
STRUCTURE 23.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
KIF26A 14q32.33 kinesin family member 26A LOC390507 14 similar to proline-rich glycoprotein (sgp158) LOC388021 14 similar to expressed sequence AI839735 MGC13251 14q32.33 hypothetical protein MGC13251 FLJ22056 14q32.33 hypothetical protein FLJ22056 LOC388022 14 hypothetical gene supported by AK131040 ADSSL1 14q32.33 adenylosuccinate synthase like 1 SIVA 14q32.33 CD27-binding (Siva) protein AKT1 14q32.32 v-akt murine thymoma viral oncogene homolog 1 LOC390508 14 similar to MGC53446 protein MGC23270 14q32.33 hypothetical protein MGC23270 RPS2P4 14q32.33 ribosomal protein S2 pseudogene 4 KIAA0284 14q32.33 KIAA0284 LOC122618 14q32.33 hypothetical protein BC015003 C14orf78 14 chromosome 14 open reading frame 78 C14orf157 14q32.33 chromosome 14 open reading frame 157 C14orf79 14q32.33 chromosome 14 open reading frame 79 CDCA4 14q32.33 cell division cycle associated 4 GPR132 14q32.3 G protein-coupled receptor 132 JAG2 14q32 jagged 2 NUDT14 14q32.33 nudix (nucleoside diphosphate linked moiety X)-type motif 14 LOC390509 14 similar to chloride intracellular channel 6; chloride channel form A BRF1 14q32.33 BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   predominantly
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Muscularstriatumskeletal predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies ortholog to murine AdSS1, muscular
Homologene
FAMILY adenylosuccinate synthetase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • playing an important role in the de novo pathway of purine nucleotide biosynthesis
  • adenylosuccinate synthase and ligase activity
  • playing a potential role in muscle metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    pathway of purine nucleotide biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • magnesium ion binding
  • GTP ion binding
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS