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FLASH GENE
Symbol APRT contributors: mct/npt - updated : 12-05-2022
HGNC name adenine phosphoribosyltransferase
HGNC id 626
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • phosphoribosyl transferase domain
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to rattus aprt
    Homologene
    FAMILY
  • purine/pyrimidine phosphoribosyltransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • synthesis of AMP from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP)
  • purine salvage pathway
  • important enzyme component of the purine recycling pathway (Silva 2008)
  • is the only enzyme known to produce AMP in cells from dietary adenine
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    purine ribonucleoside salvage
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) APRT
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS