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FLASH GENE
Symbol APRT contributors: mct/npt - updated : 12-05-2022
HGNC name adenine phosphoribosyltransferase
HGNC id 626
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary   
 male systemprostate   
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • phosphoribosyl transferase domain
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to rattus aprt
    Homologene
    FAMILY
  • purine/pyrimidine phosphoribosyltransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • synthesis of AMP from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP)
  • purine salvage pathway
  • important enzyme component of the purine recycling pathway (Silva 2008)
  • is the only enzyme known to produce AMP in cells from dietary adenine
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    purine ribonucleoside salvage
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) APRT
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS