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FLASH GENE
Symbol DDN contributors: mct - updated : 27-08-2015
HGNC name dendrin
HGNC id 24458
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two putative NLS (NLS1 and NLS2),
  • three PPXY motifs (P1, P2, and P3)
  • C-Terminus of dendrin interacts with nephrin
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    text
  • nuclear relocation of dendrin in response to glomerular injury promotes podocyte apoptosis
    • basic FUNCTION
  • a putative modulator of the postsynaptic cytoskeleton
  • slit diaphragms protein with proapoptotic signaling properties that accumulates in the podocyte nucleus in response to glomerular injury
  • acting as an enhancer of apoptosis
  • its expression during glomerulogenesis and in the normal human kidney is similar to that previously shown for nephrin, which suggests that dendrin associates with the slit diaphragm complex
  • is an important component of cytoskeletal modifications at the synapse
  • having a a surveillance function at the slit diaphragms and relocates to the podocyte nucleus in response to glomerular injury, thereby providing a signaling mechanism whereby changes in slit diaphragms function modulate podocyte survival
  • dual compartment protein with proapoptotic signaling properties
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the slit diaphragms complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds directly to nephrin and CD2AP, by its C-terminus
  • YAP1 binding to dendrin is a prosurvival mechanism
  • dendrin binds to WTIP and GADD45A (WTIP and GADD45A mediate gene transcription in the nucleus, suggesting that dendrin may have similar functions in podocytes
  • DDN is phosphorylated by FYN and dephosphorylated by PTPN1, and FYN-induced phosphorylation prevents NEDD4L-mediated ubiquitination of dendrin
  • MAGI2 and FYN protect DDN from NEDD4L-mediated ubiquitination and from nuclear translocation, thereby maintaining the physiologic homeostasis of podocytes, and the lack of MAGI2 in podocytes results in glomerulosclerosis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • relocation of dendrin to the podocyte nuclei is useful as a novel marker of podocyte injury in human glomerulopathy
    • Therapy target
    ANIMAL & CELL MODELS