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FLASH GENE

Symbol

DDN

contributors: mct - updated : 27-08-2015

HGNC name	dendrin
HGNC id	24458

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	4.00 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015086 2 - 3744 NP_055901 81 711 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       predominantly Homo sapiens Urinary kidney nephron renal capsule glomerulus   Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Urinary podocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two putative NLS (NLS1 and NLS2),
	three PPXY motifs (P1, P2, and P3)
	C-Terminus of dendrin interacts with nephrin

HOMOLOGY

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,nucleus
text	nuclear relocation of dendrin in response to glomerular injury promotes podocyte apoptosis

basic FUNCTION	a putative modulator of the postsynaptic cytoskeleton
	slit diaphragms protein with proapoptotic signaling properties that accumulates in the podocyte nucleus in response to glomerular injury
	acting as an enhancer of apoptosis
	its expression during glomerulogenesis and in the normal human kidney is similar to that previously shown for nephrin, which suggests that dendrin associates with the slit diaphragm complex
	is an important component of cytoskeletal modifications at the synapse
	having a a surveillance function at the slit diaphragms and relocates to the podocyte nucleus in response to glomerular injury, thereby providing a signaling mechanism whereby changes in slit diaphragms function modulate podocyte survival
	dual compartment protein with proapoptotic signaling properties

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the slit diaphragms complex

INTERACTION

DNA

RNA

small molecule

protein	binds directly to nephrin and CD2AP, by its C-terminus
	YAP1 binding to dendrin is a prosurvival mechanism
	dendrin binds to WTIP and GADD45A (WTIP and GADD45A mediate gene transcription in the nucleus, suggesting that dendrin may have similar functions in podocytes
	DDN is phosphorylated by FYN and dephosphorylated by PTPN1, and FYN-induced phosphorylation prevents NEDD4L-mediated ubiquitination of dendrin
	MAGI2 and FYN protect DDN from NEDD4L-mediated ubiquitination and from nuclear translocation, thereby maintaining the physiologic homeostasis of podocytes, and the lack of MAGI2 in podocytes results in glomerulosclerosis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	relocation of dendrin to the podocyte nuclei is useful as a novel marker of podocyte injury in human glomerulopathy
Therapy target

ANIMAL & CELL MODELS