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FLASH GENE
Symbol MAML3 contributors: mct/pgu - updated : 31-08-2013
HGNC name mastermind-like 3 (Drosophila)
HGNC id 16272
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 7086 121.5 1133 - 2002 1238615
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Lymphoid/Immunelymph node   highly
Nervousbrainhindbraincerebellum  
Reproductivefemale systemovary   
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved basic domain in their N termini that binds to the ankyrin repeat domain of Notch
  • two consensus sites for SUMOylation at Lysine217 and Lysine299
  • a transcriptional activation domain in the C terminus
    • HOMOLOGY
    interspecies ortholog to murine Maml3 (86 pc)
    Homologene
    FAMILY
  • mastermind family
    • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • putative regulator for notch signaling
  • possibly involved in regulating neurodevelopment or neuroplasticity
  • transcriptional regulators in Notch signaling
  • engagement of Mastermind (Mam) is essential for Notch signaling, and MAML1, MAML2, MAML3 have distinct roles
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS