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FLASH GENE
Symbol ZAR1 contributors: mct/npt - updated : 31-03-2010
HGNC name zygote arrest 1
HGNC id 20436
DNA
TYPE functioning gene
STRUCTURE 4.11 kb     4 Exon(s)    single Copie(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1438 - 424 - Uzbekova (2006)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary   
 male systemtestis   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveoocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text early embryon
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C terminal PHD motif
  • atypical plant homeobox zing finger domain, suggesting its role in transcription regulation (Uzbekova 2006)
  • HOMOLOGY
    interspecies homolog to murine Zar1
    Homologene
    FAMILY
  • ZAR1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • functioning at the oocyte-to-gamete transition with key role for the initiation of embryogenesis (Wu 2003)
  • ovary-specific maternal factor that plays essential roles during the oocyte-to-embryo transition (Wu 2003)
  • ZAR1 could also be implicated in the regulation of meiosis and post meiotic differentiation of male and female germ cells (Uzbekova 2006)
  • central role in early reproductive processes (Uzbekova 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS