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FLASH GENE
Symbol LCAT contributors: - updated : 24-06-2006
HGNC name lecithin-cholesterol acyltransferase
HGNC id 6522
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies ortholog to murine Lcat
ortholog to rattus Lcat
Homologene
FAMILY
  • AB hydrolase superfamily
  • lipase family
    • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • acting as a central enzyme in the extracellular metabolism of plasma lipoproteins
  • invovlved in the esterification of the free cholesterol transported in plasma lipoproteins
  • converting cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high density lipoproteins
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling sensory transduction/vision
  • cholesterol metabolism
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LCAT , FED
    Susceptibility to familial combined hyperlipemia and premature coronary artery disease
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS