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FLASH GENE
Symbol LCAT contributors: - updated : 24-06-2006
HGNC name lecithin-cholesterol acyltransferase
HGNC id 6522
DNA
TYPE functioning gene
STRUCTURE 4.00 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D16S528E - LCAT LCAT - TAT - PSMB10 - CTRL - PSKH1 - D16S124 - qter
Authors Frengen (95,97)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveliver   lowly
 stomach   moderately
Lymphoid/Immunespleen   moderately
Nervousbrain   lowly
Reproductivemale systemprostate  predominantly
Urinarybladder   highly
Visualeyeretina  lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies ortholog to murine Lcat
ortholog to rattus Lcat
Homologene
FAMILY
  • AB hydrolase superfamily
  • lipase family
    • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • acting as a central enzyme in the extracellular metabolism of plasma lipoproteins
  • invovlved in the esterification of the free cholesterol transported in plasma lipoproteins
  • converting cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high density lipoproteins
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling sensory transduction/vision
  • cholesterol metabolism
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LCAT , FED
    Susceptibility to familial combined hyperlipemia and premature coronary artery disease
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS