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FLASH GENE
Symbol KLHL41 contributors: mct - updated : 14-01-2014
HGNC name kelch-like family member 41
HGNC id 16905
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one BTB/POZ domain
  • five Kelch domains
    • HOMOLOGY
    Homologene
    FAMILY family of BTB-Kelch domain-containing proteins
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleolus
    text
  • localizes over (but not within) I bands, likely in association with the terminal cisternae of the sarcomplasmic reticulum (SR) (PMID;
    • basic FUNCTION
  • required for pseudopod elongation in transformed cells
  • has a role in cytoskeletal organization and cell motility
  • role in skeletal muscle development and differentiation
  • critical role of BTB-Kelch family members in maintenance of sarcomeric integrity in nemaline myopathy
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • through Kelch repeats interact directly with LASP1 in membrane ruffles at the tips of pseudopodia, where both proteins are necessary for pseudopodial elongation
  • interacts with nebulin, NRAP (Nebulin-related anchoring protein), and actin in skeletal muscle and promotes the assembly of myofibrils
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS