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FLASH GENE

Symbol

KLHL41

contributors: mct - updated : 14-01-2014

HGNC name	kelch-like family member 41
HGNC id	16905

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	16.56 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006063 6 - 2472 NP_006054 - 606 - -

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         muscular sarcomere         Respiratory diaphragm         Mus musculus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal     Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

pancreas

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one BTB/POZ domain
	five Kelch domains

HOMOLOGY

Homologene

FAMILY

family of BTB-Kelch domain-containing proteins

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,nucleus,nucleolus
text	localizes over (but not within) I bands, likely in association with the terminal cisternae of the sarcomplasmic reticulum (SR) (PMID;

basic FUNCTION	required for pseudopod elongation in transformed cells
	has a role in cytoskeletal organization and cell motility
	role in skeletal muscle development and differentiation
	critical role of BTB-Kelch family members in maintenance of sarcomeric integrity in nemaline myopathy

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	through Kelch repeats interact directly with LASP1 in membrane ruffles at the tips of pseudopodia, where both proteins are necessary for pseudopodial elongation
	interacts with nebulin, NRAP (Nebulin-related anchoring protein), and actin in skeletal muscle and promotes the assembly of myofibrils

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS