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FLASH GENE
Symbol G6PC2 contributors: mct - updated : 07-03-2011
HGNC name glucose-6-phosphatase, catalytic, 2
HGNC id 28906
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine G6pc2
Homologene
FAMILY PA-phosphatase related phosphoesterase family
CATEGORY enzyme , transport channel
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • may be a single membrane channel protein acting both as a hydrolase and a translocase
  • key enzyme in homeostatic regulation of blood glucose levels
  • may underlie variation in fasting glucose, though it is possible that ABCB11, which is expressed primarily in liver, may also contribute to such variation
  • Glucokinase (GCK) and G6PC2 regulate the glucose-cycling step in pancreatic beta-cells and may regulate insulin secretion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by endoplasmic reticulum stress (increases glucose-6-phosphatase and glucose cycling in liver cells)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to type 2 diabetes
  • to variation of fasting glucose concentrations
    • Variant & Polymorphism SNP
  • SNPs from G6PC2 associated with type 2 diabetes (G6PC2 genetic variants were associated to both first- and second-phases insulin secretion)
  • significant association between the SNP rs563694 and fasting glucose concentrations
    • Candidate gene G6PC2 inhibitors may be an attractive new approach for the treatment of insulin secretion defects in type 2 diabetes
    Marker
    Therapy target
    ANIMAL & CELL MODELS