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FLASH GENE

Symbol

G6PC2

contributors: mct - updated : 07-03-2011

HGNC name	glucose-6-phosphatase, catalytic, 2
HGNC id	28906

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021176 5 - 3096 - 355 expressed in the pancreas but not in thymus or spleen 2006 16520917 NM_001081686 4 - 2980 - 154 pancreas, thymus , spleen 2006 16520917

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Endocrine islet cell (alpha,beta...) Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

ortholog to murine G6pc2

Homologene

FAMILY

PA-phosphatase related phosphoesterase family

CATEGORY

enzyme , transport channel

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	may be a single membrane channel protein acting both as a hydrolase and a translocase
	key enzyme in homeostatic regulation of blood glucose levels
	may underlie variation in fasting glucose, though it is possible that ABCB11, which is expressed primarily in liver, may also contribute to such variation
	Glucokinase (GCK) and G6PC2 regulate the glucose-cycling step in pancreatic beta-cells and may regulate insulin secretion

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

induced by

endoplasmic reticulum stress (increases glucose-6-phosphatase and glucose cycling in liver cells)

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to type 2 diabetes to variation of fasting glucose concentrations

Variant & Polymorphism SNP	SNPs from G6PC2 associated with type 2 diabetes (G6PC2 genetic variants were associated to both first- and second-phases insulin secretion)
	significant association between the SNP rs563694 and fasting glucose concentrations

Candidate gene	G6PC2 inhibitors may be an attractive new approach for the treatment of insulin secretion defects in type 2 diabetes
Marker
Therapy target

ANIMAL & CELL MODELS