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FLASH GENE
Symbol FOXQ1 contributors: mct - updated : 03-12-2015
HGNC name forkhead box Q1
HGNC id 20951
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two putative transcriptional activation domain
  • one fork-head DNA-binding domain
    • HOMOLOGY
    interspecies ortholog to murine Foxq1
    Homologene
    FAMILY
  • member of the cancer-related FOX family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in development during embryogenesis
  • HOXC13 and FOXQ1 control medulla differentiation of the hair through a common regulatory pathway
  • potential functional roles, for epithelial plasticity
  • involved in regulation of transcription, DNA-dependent
  • critical functional role for the Forkhead transcription factor FOXQ1 in regulating EMT in breast cancer cells
  • FOXQ1-induced EMT was associated with transcriptional inactivation of the epithelial regulator E-cadherin (CDH1)
  • a key role for FOXQ1 in regulating EMT and aggressiveness in human cancer
  • FOXC1, GMDS, FOXF2, and FOXQ1 may represent loci for enhancer-driven changes in gene expression that could affect the developing embryo
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • FOXF1 and FOXQ1 directly bind to distinct regions of MYOCD
  • directly bound to the SOX12 promoter and transactivated its expression, which contributed to SOX12 overexpression in human hepatocellular carcinoma
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal and lung carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS