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FLASH GENE

Symbol

KRT19

contributors: mct/npt - updated : 31-03-2016

HGNC name	keratin 19
HGNC id	6436

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   aberrantly expressed in hepatocellular carcinoma expressing having a higher rate of recurrence

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	both KRT19 and ANXA8 mRNA may be useful markers for detecting lymph node metastases in OSCC (oral squamous cell carcinoma) patients
	sensitive marker to identify yolk sac tumours of the testis and to distinguish them from other germ cell tumours, especially seminomas and embryonic carcinomas
	used as a biomarker for the detection of disseminated tumors
	KRT19 expression can be used as a prognostic marker in breast cancer
	high levels of fecal KRT19 mRNA represent a potential marker for colorectal malignancy and for aggressive treatment of younger CRC patients
Therapy target

ANIMAL & CELL MODELS

tibialis anterior (TA) muscles of mice lacking keratin 19 (K19) lose costameres, accumulate mitochondria under the sarcolemma, and generate lower specific tension than controls