basic FUNCTION
| may be playing a role in RNA metabolism |
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required for accurate expression of genes important for proper brain, skeletal, and blood cell development |
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might play an important role in Fas-mediated apoptosis |
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implicated in ribosome biogenesis, and having a role in stabilized the mitotic spindle to prevent genomic instability |
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multi-functional protein, having a function beyond ribosome biogenesis (may provide insight into the poorly understood cancer predisposition of SBDS patients) |
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its essential role is to tightly couple GTP hydrolysis by EFL1 on the ribosome to EIF6 release |
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SBDS and EFNA1 directly catalyze EIF6 removal in mammalian cells by a mechanism that requires GTP binding and hydrolysis by EFNA1 but not phosphorylation of EIF6 Ser 235 |
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direct role for SBDS and EFNA1 in catalyzing the translational activation of ribosomes |
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potential role for SBDS in nuclear export of ribosomal pre-60S subunits |
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influence many cellular processes including ribosome biogenesis, mitotic spindle assembly, chemotaxis, and the regulation of reactive oxygen species production |
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SBDS protein is important for ribosome maturation |
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is a protein required for the maturation of 60S ribosomes |
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SBDS is a telomere-protecting protein that participates in regulating telomerase recruitment |