basic FUNCTION
| involved in planar cell polarity |
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required for normal localization of specific intraflagellar transport and in general intracellular transport |
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required for the localization of G protein-coupled receptors to primary cilia on central neurons |
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mediate LEPR trafficking and impaired LEPR signaling underlies energy imbalance in the disease |
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could participate, at the base of cilia, in a gate-keeping mechanism that allows only appropriate proteins access to the ciliary compartment |
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play a central role in the regulation of the actin cytoskeleton and control the cilia length through alteration of RHOA levels |
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potential role for TTC8 and/or IFT20, possibly upstream of core planar cell polarity (PCP) asymmetry |
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ciliary genes FAM161A and TTC8 have been implicated in retinal degeneration (RD) |