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FLASH GENE
Symbol PILRA contributors: mct/pgu - updated : 13-04-2010
HGNC name paired immunoglobin-like type 2 receptor alpha
HGNC id 20396
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an Ig-like cysteine-based motif involved in intradomain disulfide bonding
  • a potential N-glycosylation site,numerous O-glycosylation sites
  • a transmembrane domain and 3 potential tyrosine phosphorylation sites, 2 of which are within an immunoreceptor tyrosine-based inhibitory motif (ITIM)
    • conjugated GlycoP , PhosphoP
    mono polymer monomer
    HOMOLOGY
    intraspecies homolog to PILR(BETA)
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6 and PTPN11 that block signal transduction through dephosphorylation of signaling molecules
  • coreceptor for HSV-1 infection
  • importance of PILRA and PILRB in innate immunity and the control of inflammation
  • PANP and PILRA interactions might be involved in neural immune disorders such as multiple sclerosis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PTPN6, PTPN11
  • associating with glycoprotein B of HSV-1
  • CD99 was recognized by both PILRA and PILRB , but PILRA can bind to CD99 with low affinity
  • binds and activates immune inhibitory receptor PILRA in trans, a process that requires sialidation of PIANP
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS