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FLASH GENE
Symbol CD300C contributors: mct - updated : 12 -11-201
HGNC name CD300c antigen
HGNC id 19320
Location 17q25.1      Physical location : 72.537.246 - 72.542.282
Synonym name
  • CMRF35 leukocyte immunoglobulin-like receptor
  • CMRF35-like molecule 6
  • immunoglobulin superfamily member 16
  • Synonym symbol(s) LIR, CMRF35A, CMRF-35A, CMRF35A1, CMRF35, IGSF16
    DNA
    TYPE functioning gene
    STRUCTURE 5.11 kb     4 Exon(s)
    text structure closely linked to CMRF35H
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1602 - 224 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemprostate   
    Respiratorylung    
    Visualeyeuveachoroid  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Blood/Hematopoieticmonocyte Homo sapiens
    not specificmast cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an immunoglobulin-like v-type domain
  • a short cytoplasmic tail in combination with a transmembrane region bearing a negatively charged AA, which theoretically would avoid transmembrane charge complementation with the known adaptor polypeptides
  • an ER retrieval motif within its 12-AA-long cytoplasmic tail
  • HOMOLOGY
    intraspecies homolog to highly homologous with CD300A
    Homologene
    FAMILY CD300 family of paired immune receptors
    CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • CD300A and CD300C are indistinguishable on the surface of NK cells 1)
  • CD300A/CD300C receptors are differentially expressed on human TH1 and TH17 cells and their ligation is capable of modulating TCR mediated signals
  • would regulate the expression of other CD300 molecules and the composition of CD300 complexes on the cell surface
  • activating receptor expressed on monocytes and having a potential role in inflammatory responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CD300C signaling is partially mediated by a direct association with the immune receptor tyrosine-based activation motif-bearing adaptor FCER1G
  • CD300LD recruited FCER1G as efficiently as CD300C
  • specific engagement of CD300C led to FCER1G-dependent activation of mast cells and monocytes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS