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FLASH GENE

Symbol

KRT18

contributors: mct/ - updated : 28-08-2018

HGNC name	keratin 18
HGNC id	6430

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CCRH

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   detectable in the vascular smooth muscle cells of atherosclerotic lesions tumoral     --over   in metastatic cells constitutional     --over   of total KRT18 serum and urine levels in CKD patients, possibly indicating that epithelial cell necrosis is prevalent in chronic kidney disease (CKD)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	KRT18 is a promising non-invasive biomarker for Nonalcoholic steatohepatitis (NASH) in children with fatty liver disease
	KRT18 is promising plasma biomarker to identify patients with HELLP syndrome
	high circulating caspase-cleaved KRT18 (CCCK18) is associated with injury severity and a poor clinical outcome after aneurysmal subarachnoid hemorrhage (aSAH)
	correlation between serum KRT18 and the progression or regression of non-alcoholic fatty liver disease
Therapy target

ANIMAL & CELL MODELS