Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

DPF3

contributors: mct - updated : 13-10-2021

HGNC name	D4, zinc and double PHD fingers, family 3
HGNC id	17427

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in the right ventricular myocardium of patients with Tetralogy of Fallot (TOF) tumoral       loss of function significantly downregulated in breast cancer tissues

Susceptibility

to breast cancer development to renal cell carcinoma (RCC)

Variant & Polymorphism other	Polymorphisms in the 5' region of DPF3 were associated with increased risk of breast cancer development, lymph node metastases, age of onset, and tumor size in women of European ancestry
	rs4903064, located in an intron of DPF3, rs4903064-C RCC risk allele creates a HIF-binding site and would be predicted to enhance gene expression, whereas the rs4903064-T protective allele is predicted to increase the affinity for the IRX2/IRX5 binding, which represses DPF3 transcription

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast downregulation of DPF3 plays an indispensable function in the progression of breast cancer, and may be served as a novel therapeutic target to therapy breast cancer cancer brain glioma/neuroblstoma DPF3a is a potential therapeutic targets for glioblastoma

ANIMAL & CELL MODELS