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FLASH GENE
Symbol ZNF318 contributors: - updated : 07-02-2007
HGNC name zinc finger protein 318
HGNC id 13578
Location 6pter-p12.1      Physical location : 43.303.808 - 43.337.181
Synonym name
  • zinc finger protein 318 homolog mouse
  • testicular zinc finger
  • Synonym symbol(s) ZFP318, FLJ21852, HRIHFB2436, TZF
    DNA
    TYPE functioning gene
    STRUCTURE 33.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Nervousnervecranial nerve  highly
    Reproductivemale systemtestis   
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoptic nerve
    Reproductivespermatid
    Reproductivespermatocyte
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a zinc finger domain of the C2H2 type, two matrin-type zinc fingers
  • four basic amino-acid rich domains
  • a myosin II-homology domain
  • conjugated MetalloP
    HOMOLOGY
    interspecies ortholog to murine Zfp318
    Homologene
    FAMILY
    CATEGORY structural protein , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • transcriptional regulator during spermatogenesis in particular, during meiotic division
  • acting as a novel corepressor of AR
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with the N-terminal domain of AR (binding to the activation function-1 (AF-1) domain (N-terminal transactivating domain) of AR protein )
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS