basic FUNCTION
| may be playing a role in transcriptional regulation |
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playing an important role in cell growth and poliferation which may be achieved via its participation in ribosomes biogenesis (at the RNA and/or protein level) |
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new X-linked tumor suppressor in T--cell acute lymphoblastic leukemia (Van Vlierberghe 2010) |
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nucleolus, ribosomal RNA promoter-associated protein |
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key function of PHF6 is involved in regulating rRNA synthesis, which may contribute to its roles in cell cycle control, genomic maintenance, and tumor suppression |
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tumor suppressor function of PHF6 may be associated with its regulatory role in rRNA synthesis, which contributes to genome maintenance |
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is required for normal cell cycle progression |
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caretaker tumor suppressor, which functions by ensuring proper rRNA synthesis to maintain genomic stability |