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FLASH GENE
Symbol TMC6 contributors: mct/npt - updated : 13-01-2009
HGNC name transmembrane channel-like 6
HGNC id 18021
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
 spleen   highly
 thymus   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text cord blood
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two leucine zipper motifs
  • ten transmembrane domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Ever1
    homolog to chimpanzee LOC454916
    homolog to chicken tmc6
    intraspecies homolog to TMC8
    Homologene
    FAMILY
  • leukocytes TMC (transmembrane channel-like gene) family
    • CATEGORY receptor membrane , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SLC30A1 (with TMC8, form a complex and interact with the zinc transporter 1, SLC30A1)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EV1
    Susceptibility susceptibility to infection with certain papillomaviruses and high risk of skin carcinoma
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS