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FLASH GENE
Symbol IVL contributors: mct - updated : 25-05-2011
HGNC name involucrin
HGNC id 6187
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • protein glutamine/glutamate rich, with 39 octapeptide repeats in the central region
    • HOMOLOGY
    interspecies ortholog to murine Ivl
    homolog to C.elegans C25A11.4B
    Homologene
    FAMILY
  • SPRR family
  • involucrin family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text cytosol protein ultimately cross-linked to membrane by transglutaminase
    basic FUNCTION
  • functioning as a keratinocyte protein
  • marker of epithelial differentiation which expression is upregulated just after basal cells are pushed into the suprabasal layer in stratified epithelia
  • with EVPL, and PPL, form the protein scaffold on which the cornified envelope assembles
  • Loricrin (LOR) and involucrin (IVL) are proteins important for skin barrier formation and integrity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • precursor of cornified cell enveloppe (major constituent of keratinocyte cross-linked enveloppe)
  • PRMT5/WDR77-dependent methylation is an epigenetic mechanism that assists in silencing of IVL expression, and PRKCD signaling activates gene expression by directly activating transcription and by suppressing PRMT5/WDR77-dependent arginine dimethylation of promoter-associated histones
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by Th2 cytokines that inhibit expression of LOR and IVL through a STAT-6 dependent mechanism
    repressed by overexpression of POU2F2 (repression of promoter activity in epithelial cells and in the presence of the silencer element)
    Other regulated by PCAF and CREBBP in stratified squamous epithelial cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS