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FLASH GENE

Symbol

IVL

contributors: mct - updated : 25-05-2011

HGNC name	involucrin
HGNC id	6187

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	3.32 kb     2 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   transcription factor
text structure	open reading frame in a single exon
	regulatory transcription factor binding sites (AP1), for regulation of expression during early versus late epidermal differentiation
	binding sites for AP-1 (activator protein 1) and Sp1 transcription factors important for promoter activity and tissue-specific expression

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see EDC

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005547 2 - 2165 - 585 - 1996 8618063

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Respiratory respiratory tract larynx       Urinary bladder

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective         Epithelial barrier/lining       skin tegument dermis

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

protein glutamine/glutamate rich, with 39 octapeptide repeats in the central region

HOMOLOGY

interspecies	ortholog to murine Ivl
	homolog to C.elegans C25A11.4B

Homologene

FAMILY	SPRR family
	involucrin family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
text	cytosol protein ultimately cross-linked to membrane by transglutaminase

basic FUNCTION	functioning as a keratinocyte protein
	marker of epithelial differentiation which expression is upregulated just after basal cells are pushed into the suprabasal layer in stratified epithelia
	with EVPL, and PPL, form the protein scaffold on which the cornified envelope assembles
	Loricrin (LOR) and involucrin (IVL) are proteins important for skin barrier formation and integrity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	precursor of cornified cell enveloppe (major constituent of keratinocyte cross-linked enveloppe)
	PRMT5/WDR77-dependent methylation is an epigenetic mechanism that assists in silencing of IVL expression, and PRKCD signaling activates gene expression by directly activating transcription and by suppressing PRMT5/WDR77-dependent arginine dimethylation of promoter-associated histones

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

inhibited by

Th2 cytokines that inhibit expression of LOR and IVL through a STAT-6 dependent mechanism

repressed by

overexpression of POU2F2 (repression of promoter activity in epithelial cells and in the presence of the silencer element)

Other

regulated by PCAF and CREBBP in stratified squamous epithelial cells

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS