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FLASH GENE

Symbol

IVD

contributors: - updated : 21-06-2006

HGNC name	isovaleryl Coenzyme A dehydrogenase
HGNC id	6186

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	IVA isovaleric acidemia
Location	15q14-q15      Physical location : 40.697.685 - 40.713.512
Synonym symbol(s)	ACAD2
EC.number	1.3.99.10

DNA

TYPE	functioning gene
STRUCTURE	13.00 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine parathyroid       highly   thyroid       highly Nervous brain         Reproductive male system prostate

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

pancreas

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , tetramer

HOMOLOGY

Homologene

FAMILY

acyl-coa dehydrogenase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix

basic FUNCTION

isovaleryl-CoA dehydrogenase, branched chain, catalyzing the third step in leucine catabolism

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	FAD

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

IVA

related resource

MITOP database

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS