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FLASH GENE

Symbol

ABR

contributors: mct - updated : 21-05-2011

HGNC name	active BCR-related gene
HGNC id	81

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

intraspecies

homolog to BCR

Homologene

FAMILY

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
text	BCR and its close relative active BCR-related (ABR) localize at excitatory synapses

basic FUNCTION	ABR and BCR are the only GTPase-activating proteins to date that specifically negatively regulate Rac function in primary macrophages
	GTPase-activating protein for the small GTPase Rac
	BCR and ABR cooperate in negatively regulating acute inflammatory responses
	BCR and ABR have novel roles in the regulation of synaptic Rac1 signaling, synaptic plasticity, and learning and memory, and that excessive Rac1 activity negatively affects synaptic and cognitive functions

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

directly interact with DLG4, an abundant postsynaptic scaffolding protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS