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FLASH GENE
Symbol HIST4H4 contributors: mct/npt - updated : 07-04-2009
HGNC name histone 4, H4
HGNC id 20510
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth    
Lymphoid/Immunespleen    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal tail may play a major regulator in chromatin structure and function
    • HOMOLOGY
    Homologene
    FAMILY
  • histone H4 family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • playing a role in mediating recruitment of multiple regulatory factors that can change chromatin states for transcription regulation (Choi 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SETD8 and L3MBTL (importance of HIST4H4 monomethylation and of SETD8 for L3MBTL function) (Kalakonda 2008)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS