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FLASH GENE

Symbol

HIST4H4

contributors: mct/npt - updated : 07-04-2009

HGNC name	histone 4, H4
HGNC id	20510

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	0.41 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed HIST4H4 1 - 412 11.24 103 - Kalakonda (2008)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth         Lymphoid/Immune spleen

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N-terminal tail may play a major regulator in chromatin structure and function

HOMOLOGY

Homologene

FAMILY

histone H4 family

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION

playing a role in mediating recruitment of multiple regulatory factors that can change chromatin states for transcription regulation (Choi 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with SETD8 and L3MBTL (importance of HIST4H4 monomethylation and of SETD8 for L3MBTL function) (Kalakonda 2008)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS